Modelling drug flux through microporated skin

Mathematical Modelling of Chemical Diffusion through Skin

The skin forms the interface between the body and the external environment. It has several functions including thermal regulation, sensory perception, excretion, and as a barrier to protect against infection, dehydration and chemical assault. Its role as a water barrier is critical to our ability to survive on land, and any significant departure from normal barrier function leads to serious hea...

Modelling the effect of mixture components on permeation through skin.

A vehicle influences the concentration of penetrant within the membrane, affecting its diffusivity in the skin and rate of transport. Despite the huge amount of effort made for the understanding and modelling of the skin absorption of chemicals, a reliable estimation of the skin penetration potential from formulations remains a challenging objective. In this investigation, quantitative structur...

Use of confocal microscopy for nanoparticle drug delivery through skin.

Confocal laser scanning microscopy (CLSM) is a well-used microscopic tool that provides valuable morphological and functional information within cells and tissues. The application of CLSM to skin and the topical penetration of nanoparticles (NP) will be addressed. First, we describe the advantages of confocal microscopy compared to other techniques and its use relative to skin research. Second,...

Drug absorption through the skin: a mixed blessing.

Flux and Concentration Footprint Modelling